Endocrine Abstracts

The importance of the Liver X receptors (LXRs) as a critical modulators of metabolic homeostasis and immunity in health and disease has been mainly gleaned from studies evaluating the consequences of their pharmacological or genetic manipulation. We previously showed LXRα is phosphorylated upon cholesterol loading. It is however unknown whether post-translational modifications of the receptor modulate diet-induced responses and affect metabolic diseases with an important ...